CLARITY v3.0 highlights

 

In November 2018, the latest version of CLARITY (v3.0) was released for clients distribution, which includes:

  • Metadata:

- Data. An expertly curated training set of 2.6 million compounds derived from patents, journals and public databases to ensure comprehensive coverage of the chemical space.
- Models. Pharmacology (3,601 targets) and Toxicology (7 Preclinical and 520 Clinical endpoints).

  • Modules:

- Drug Explorer

- FAERS Explorer  (New in v3.0)

- Predictive Analytics

- Panel Manager

 

This new version includes as improvements to previous release:

  • An Indications tab in the Drug Explorer module.

  • Option to customized Pharmacology or Toxicology profiling, with a one-click custom panel creation by target family (e.g., kinases or nuclear receptors) or toxicology category (e.g., all endpoints related to CardioTox).

  • Higher GUI navigation speed and better global performance.

Drug Explorer, module that allows the user to explore (browse and filter) background data present in the CLARITYⓇ database. PHARMACOLOGY (targets) and TOXICOLOGY (events) information are displayed and can be filtered for a deeper analysis of known data and precalculated predictions.

FAERS Explorer, an analytics module that presents the user with curated FDA’s Adverse Event Reporting system data  (from 2004 to June 2018) in a browsable environment where information for either drugs or safety events can be analyzed. 

Predictive Analytics, module that displays the summary cards of all the molecule sets in the working environment that a user has uploaded. Each card corresponds to a user job (e.g., upload molecule/s, run pharmacology and/or toxicology profiling).
 

Panel Manager, module that contains sets of Pharmacology and Toxicology models, grouped by protein family/subfamilies or safety category/endpoints. Panels can be defined from known standard panels or customized by user preferences.