| Presentation |
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Chemotargets S.L. was created on March 2006 as a spin-off initiative from the Chemogenomics Laboratory under the auspices of the Municipal Institute of Medical Research (IMIM-Hospital del Mar). The company is currently located within the impressive new premises of the Barcelona Biomedical Research Park rigth in front of the Barcelona beach, in an area that is called to become the center of the new BioRegion of Catalonia. Chemotargets core in silico pharmacology platform currently allows for providing an affinity alert when profiling small molecules on 342 targets organised in the main protein families of therapeutical relevance, namely, enzymes (231), GPCRs (86), and nuclear receptors (25). This platform is being exploited through collaboration agreements with drug discovery and chemical partners aiming at (i) designing chemical libraries directed to particular sets of disease-related targets or entire protein families, (ii) identifying new chemical entities with customised affinity profiles (hit identification), and (iii) identifying potential off-targets at which compounds designed for a particular target may have residual affinity (target fishing). The company has also developed a proprietary software for the construction of medchem isosteric libraries around know bioactive ligands to assist in hit and lead optimisation programs. The method is called SHIFT, which stands for Scaffold Hopping by Isosteric Fragment Transformations. |